Executive Order 13849, signed on September 20, 2018, formalized the Trump administration's implementation of sanctions authorized under the Countering America's Adversaries Through Sanctions Act (CAATSA), a law passed by Congress in 2017. The executive order directed the Treasury Department and State Department to designate and impose financial restrictions on individuals and entities identified under CAATSA's authorities targeting Russian, Iranian, and North Korean actors. This mechanism allowed the administration to bypass the typical interagency review process by consolidating sanctioning authority within the executive branch, granting Treasury the power to freeze assets and restrict financial transactions without necessarily returning to Congress for approval on individual designations.

The direct consequences of this order affected a broad range of American economic actors. U.S. companies faced legal restrictions on conducting any business with designated foreign entities, creating compliance burdens and forfeiting profitable international transactions. American financial institutions were prohibited from processing transactions involving sanctioned parties, effectively cutting off these individuals and entities from the global banking system. Beyond corporations, Americans with assets held by sanctioned foreign banks or individuals faced potential freezing of those assets, while travelers with connections to sanctioned countries encountered heightened scrutiny and restrictions.

This action represented an escalation in the administration's approach to adversarial nations, establishing a pattern that intensified throughout subsequent years. The sanctions framework provided the legal foundation for later measures including the 2026 continuation of the national emergency with respect to Iran and additional executive orders addressing Iranian government threats. The maritime blockade deployment against Iran in April 2026 operated within the enforcement infrastructure established by this initial sanctioning authority, demonstrating how the 2018 order became embedded in the administration's broader containment strategy across multiple administrations.

The executive order's legal foundation in CAATSA provided statutory cover that made formal court challenges difficult, though the breadth of designating power raised questions about due process protections for affected individuals. Congressional oversight remained limited, as the law delegated significant discretionary authority to the executive branch to identify sanctionable parties.